Insights & Articles

Explore the latest in generic medicines, healthcare innovation, and clinical practice.

Acetaminophen – The All-Rounder in Modern Medicine

By Aethelgard Genomics • Sep 2025

What is Acetaminophen?

  • Over-the-counter (OTC) analgesic (pain reliever) and antipyretic (fever reducer)
  • Widely used for mild to moderate pain and fever management
  • Often combined with other drugs to enhance effects

Mechanism of Action (MOA)

  • Central COX inhibition reduces prostaglandins
  • Acts on hypothalamus to lower fever
  • May interact with endocannabinoid system for pain relief
  • Minimal anti-inflammatory action (unlike NSAIDs)
  • Safer for the stomach compared to NSAIDs

Uses

  • Fever management
  • Headache, migraine, muscle pain, dental pain
  • Osteoarthritis, menstrual cramps
  • Preferred when NSAIDs are contraindicated

Dosage Guidelines

  • Adults: 500–1000 mg every 4–6 hours (Max 4000 mg/day)
  • Children: 10–15 mg/kg per dose
  • Liver disease: Reduced dose required

Side Effects

  • Common: Nausea, Stomach upset, Rash
  • Serious (Overdose): Liver toxicity, Acute liver failure, Rare kidney damage

Why Acetaminophen Stands Out

  • Safe across all ages
  • Less gastric side effects than NSAIDs
  • No effect on platelets
  • Affordable and widely available

Important Do’s & Don’ts

Do’s
  • Take recommended doses only
  • Use for fever and mild to moderate pain
  • Check labels when using combination medications
  • Consult a doctor if pregnant or taking other medications
Don’ts
  • Do not exceed 4000 mg/day for adults
  • Avoid alcohol as it increases liver damage risk
  • Do not self-medicate if liver disease is present
  • Do not delay medical help in case of overdose

Artificial Intelligence in Healthcare: Global Developments, India's Journey, Concerns, and the Future

By Aethelgard Genomics • Sep 2025

Recent Global Developments

AI is moving from research to clinical practice with accelerated efforts worldwide. The World Health Organization (WHO) emphasizes safe, equitable AI deployment with governance and transparency.

The U.S. FDA published draft guidance on AI/ML-enabled medical devices, focusing on safety, monitoring, and real-world performance (2025).

Validated AI applications include imaging, cardiology, pathology, emergency workflows, and remote monitoring (e.g., AI diagnostic stethoscopes, radiology triage).

Key Uses and Benefits of AI in Healthcare

Medical imaging: Faster reads and prioritization for screening and triage.

Predictive analytics: Risk scoring for sepsis, readmissions, and patient deterioration.

Drug discovery: Accelerated identification of drug candidates and trial design.

Virtual assistants/chatbots: Patient triage, medication reminders, and administrative automation.

Operational efficiency: Scheduling, supply chain optimization, and billing automation.

AI in Healthcare — The Indian Context

India’s digital health transformation includes initiatives like Ayushman Bharat Digital Mission (ABDM) which builds interoperable digital health infrastructure (unique health IDs, digital records).

Practical AI deployments in India include AI-driven radiology and ophthalmology screening programs, telemedicine platforms using NLP/chatbots for basic triage, and state-level pilots with conversational agents for maternal and public health support.

Legal, Ethical, and Cultural Concerns in India

Data protection and privacy: Governed by Digital Personal Data Protection Act (DPDP Act) 2023 and rules in 2024-2025 regulating consent and data transfers.

Informed consent and trust: Diversity and digital literacy gaps require robust consent in local languages.

Bias and equity: Urban-centric datasets risk underperformance for rural or low-resource populations.

Regulatory clarity and liability: Unclear responsibility for AI-driven clinical errors among developers, hospitals, and clinicians.

Practical Recommendations for India

Build representative datasets; use federated learning to protect privacy and improve model generalizability.

Prioritize explainability and human-in-the-loop approaches; AI should assist, not replace clinicians.

Strengthen consent and patient education in local languages with opt-out options and transparency.

Implement continuous post-market monitoring to detect bias and performance drift.

Ensure compliance with DPDP Act and health sector regulations; embed privacy-by-design principles.

The Future: Next 5–10 Years

AI will evolve from task-specific tools to integrated clinical workflows and population health platforms.

Expect more regulated AI devices with clear lifecycle oversight (training, validation, monitoring).

Increased use of real-world evidence for model updating and personalized medicine.

Expansion of low-cost, offline edge AI devices for rural screening (eye, TB, maternal health).

Policy evolution to clarify liability, standardize validation datasets, and enable safe cross-border data flow.

Conclusion

AI offers transformative potential for healthcare globally and in India by increasing access and enabling precision medicine. Achieving these benefits requires deliberate policy, culturally sensitive approaches, data representativeness, and strong legal protections to ensure trust, equity, and safety.